Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance

被引：110

作者：

Busquets, Silvia ^{[1
,2
,5
]}

Toledo, Miriam ^{[1
]}

Orpi, Marcel ^{[1
]}

Massa, David ^{[1
]}

Porta, Maria ^{[1
]}

Capdevila, Eva ^{[1
]}

Padilla, Nuria ^{[1
]}

Frailis, Valentina ^{[1
]}

Lopez-Soriano, Francisco J. ^{[1
,2
]}

Han, H. Q. ^{[3
,4
]}

Argiles, Josep M. ^{[1
,2
]}

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Canc Res Grp, E-08028 Barcelona, Spain

[2] Univ Barcelona IBUB, Inst Biomed, Barcelona, Spain

[3] Amgen Res, Dept Metab Disorders, Thousand Oaks, CA 91320 USA

[4] Amgen Res, Dept Prot Sci, Thousand Oaks, CA 91320 USA

[5] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | 2012年 / 3卷 / 01期

关键词：

Myostatin; Cancer cachexia; Skeletal muscle; Physical activity; Muscle force; Ubiquitin; BETA SUPERFAMILY MEMBER; SKELETAL-MUSCLE; CANCER CACHEXIA; CA2+-DEPENDENT PROTEOLYSIS; GROWTH; MASS; CELLS; GENE; RATS; DEGRADATION;

D O I：

10.1007/s13539-011-0049-z

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Background Cachexia is a multiorganic syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting and inflammation. Methods The aim of this investigation was to examine the effect of the soluble receptor antagonist of myostatin (sActRIIB) in cachectic tumor-bearing animals analyzing changes in muscle proteolysis and in quality of life. Results Administration of sActRIIB resulted in an improvement in body and muscle weights. Administration of the soluble receptor antagonist of myostatin also resulted in an improvement in the muscle force. Conclusions These results suggest that blocking myostatin pathway could be a promising therapeutic strategy for the treatment of cancer cachexia.

引用

页码：37 / 43

页数：7

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