Diminished expression and function of TLR in lymphatic filariasis: A novel mechanism of immune dysregulation

被引：97

作者：

Babu, S

Blauvelt, CP

Kumaraswami, V

Nutman, TB

机构：

[1] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] TB Res Ctr, Madras, Tamil Nadu, India

来源：

JOURNAL OF IMMUNOLOGY | 2005年 / 175卷 / 02期

关键词：

D O I：

10.4049/jimmunol.175.2.1170

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphatic filariasis is a disease characterized by immune dysregulation involving APC and T cell populations. To assess the contribution of TLR in mediating this dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of filaria-infected and uninfected individuals. Baseline expression of TLR was significantly lower in B cells but not in monocytes of the filaria-infected group compared with the uninfected group. Upon stimulation with filarial Ag, a diminished up-regulation of TLR was observed in both B cells and monocytes of infected individuals. Finally, stimulation of B cells and monocytes with TLR ligands resulted in decreased B cell and monocyte activation/cytokine production, indicating a state of immune tolerance. This dysregulation is associated with diminished CD4(+) T cell production of IFN-gamma and IL-5. The diminished expression and function of TLR is thus a likely consequence of chronic Ag stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in filariasis.

引用

收藏

页码：1170 / 1176

页数：7

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