The effect of age on expression of endogenous plasminogen activators after focal cerebral ischemia in mice

被引:8
作者
Ahn, MY
Zhang, ZG
Zhang, L
Chopp, M
机构
[1] Soonchunhyang Univ Hosp, Dept Neurol, Seoul 140743, South Korea
[2] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA
[3] Oakland Univ, Dept Phys, Rochester, MI 48309 USA
关键词
t-PA; u-PA; age; middle cerebral artery occlusion; mouse;
D O I
10.1016/S0006-8993(99)01430-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We measured urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) activity in the brain of 2-3 month old and 6-8 month old mice subjected to 4 h of middle cerebral artery (MCA) occlusion, t-PA activity was present in all non-ischemic and ischemic young mouse brain. In contrast, t-PA activity was present in 46.7% of non-ischemic middle aged mouse brain and in 44.4% of ischemic middle aged mouse brain. u-PA activity was present in all young and middle aged non-ischemic brains. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:112 / 116
页数:5
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