Arp2/3 complex: Advances on the inner workings of a molecular machine

被引：30

作者：

Cooper, JA ^{[1
]}

Wear, MA ^{[1
]}

Weaver, AM ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Cell Biol, St Louis, MO 63130 USA

来源：

CELL | 2001年 / 107卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(01)00605-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several new papers report progress on the structure and function of Arp2/3 complex. A crystal structure, a cryo-EM structure, and a reconstitution of the complex from subunits have been reported. New results also address the nucleation mechanism and the role of bound nucleotide.

引用

页码：703 / 705

页数：3

共 18 条

[1] Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy [J].

Amann, KJ ;

Pollard, TD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) :15009-15013

[2] The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments [J].

Amann, KJ ;

Pollard, TD .

NATURE CELL BIOLOGY, 2001, 3 (03) :306-310

[3] The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension [J].

Bailly, M ;

Ichetovkin, I ;

Grant, W ;

Zebda, N ;

Machesky, LM ;

Segall, JE ;

Condeelis, J .

CURRENT BIOLOGY, 2001, 11 (08) :620-625

[4] Actin machinery: pushing the envelope [J].

Borisy, GG ;

Svitkina, TM .

CURRENT OPINION IN CELL BIOLOGY, 2000, 12 (01) :104-112

[5] Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments [J].

Dayel, MJ ;

Holleran, EA ;

Mullins, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) :14871-14876

[6] Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex [J].

Duncan, MC ;

Cope, MJTV ;

Goode, BL ;

Wendland, B ;

Drubin, DG .

NATURE CELL BIOLOGY, 2001, 3 (07) :687-690

[7] Activation of the Arp2/3 complex by the actin filament binding protein Abp1p [J].

Goode, BL ;

Rodal, AA ;

Barnes, G ;

Drubin, DG .

JOURNAL OF CELL BIOLOGY, 2001, 153 (03) :627-634

[8] Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity [J].

Gournier, H ;

Goley, ED ;

Niederstrasser, H ;

Trinh, T ;

Welch, MD .

MOLECULAR CELL, 2001, 8 (05) :1041-1052

[9] Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins [J].

Higgs, HN ;

Pollard, TD .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :649-676

[10]

ICHETOVKIN I, 2001, IN PRESS CURR BIOL

← 1 2 →