Accuracy of available methods for quantifying the heat power generation of nanoparticles for magnetic hyperthermia

被引:130
作者
Andreu, Irene [1 ]
Natividad, Eva [1 ]
机构
[1] Univ Zaragoza, CSIC, ICMA, Zaragoza, Spain
关键词
Calorimetric methods; magnetic hyperthermia; magnetic methods; magnetic nanoparticles; specific absorption rate; IRON-OXIDE NANOPARTICLES; ABSORPTION RATE; PROSTATE-CANCER; IN-VITRO; TEMPERATURE; FIELD; FLUID; THERMOTHERAPY; DEPENDENCE; SYSTEM;
D O I
10.3109/02656736.2013.826825
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In magnetic hyperthermia, characterising the specific functionality of magnetic nanoparticle arrangements is essential to plan the therapies by simulating maximum achievable temperatures. This functionality, i.e. the heat power released upon application of an alternating magnetic field, is quantified by means of the specific absorption rate (SAR), also referred to as specific loss power (SLP). Many research groups are currently involved in the SAR/SLP determination of newly synthesised materials by several methods, either magnetic or calorimetric, some of which are affected by important and unquantifiable uncertainties that may turn measurements into rough estimates. This paper reviews all these methods, discussing in particular sources of uncertainties, as well as their possible minimisation. In general, magnetic methods, although accurate, do not operate in the conditions of magnetic hyperthermia. Calorimetric methods do, but the easiest to implement, the initial-slope method in isoperibol conditions, derives inaccuracies coming from the lack of matching between thermal models, experimental set-ups and measuring conditions, while the most accurate, the pulse-heating method in adiabatic conditions, requires more complex set-ups.
引用
收藏
页码:739 / 751
页数:13
相关论文
共 126 条
[1]  
Ahrentorp F, 2010, AIP CONF PROC, V1311, P213, DOI 10.1063/1.3530015
[2]   Heat Production by Bacterial Magnetosomes Exposed to an Oscillating Magnetic Field [J].
Alphandery, E. ;
Faure, S. ;
Raison, L. ;
Duguet, E. ;
Howse, P. A. ;
Bazylinski, D. A. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2011, 115 (01) :18-22
[3]  
Andreu I, 2010, 11 C NAC MAT ZAR SPA
[4]   High heat generation ability in AC magnetic field for nano-sized magnetic Y3Fe5O12 powder prepared by bead milling [J].
Aono, Hiromichi ;
Ebara, Hiroki ;
Senba, Ryota ;
Naohara, Takashi ;
Maehara, Tsunehiro ;
Hirazawa, Hideyuki ;
Watanabe, Yuji .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2012, 324 (12) :1985-1991
[5]   Effect of bead milling on heat generation ability in AC magnetic field of FeFe2O4 powder [J].
Aono, Hiromichi ;
Watanabe, Yusuke ;
Naohara, Takashi ;
Maehara, Tsunehiro ;
Hirazawa, Hideyuki ;
Watanabe, Yuji .
MATERIALS CHEMISTRY AND PHYSICS, 2011, 129 (03) :1081-1088
[6]   Magnetic nanoparticles coated by temperature responsive copolymers for hyperthermia [J].
Aqil, A. ;
Vasseur, S. ;
Duguet, E. ;
Passirani, C. ;
Benoit, J. P. ;
Jerome, R. ;
Jerome, C. .
JOURNAL OF MATERIALS CHEMISTRY, 2008, 18 (28) :3352-3360
[7]   USABLE FREQUENCIES IN HYPERTHERMIA WITH THERMAL SEEDS [J].
ATKINSON, WJ ;
BREZOVICH, IA ;
CHAKRABORTY, DP .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1984, 31 (01) :70-75
[8]   Critical RF losses in fine particles of La1-xAgyMnO3+δ: Prospects for temperature-controlled hyperthermia [J].
Atsarkin, V. A. ;
Generalov, A. A. ;
Demidov, V. V. ;
Mefed, A. E. ;
Markelova, M. N. ;
Gorbenko, O. Yu. ;
Kaul, A. R. ;
Roy, E. J. ;
Odintsov, B. M. .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2009, 321 (19) :3198-3202
[9]   Superparamagnetic gel as a novel material for electromagnetically induced hyperthermia [J].
Babincová, M ;
Leszczynska, D ;
Sourivong, P ;
Cicmanec, P ;
Babinec, P .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) :109-112
[10]   HEAT-CAPACITY MEASUREMENTS ON SMALL SAMPLES AT LOW-TEMPERATURES [J].
BACHMANN, R ;
SCHWALL, RE ;
THOMAS, HU ;
ZUBECK, RB ;
KING, CN ;
KIRSCH, HC ;
DISALVO, FJ ;
GEBALLE, TH ;
LEE, KN ;
HOWARD, RE ;
GREENE, RL .
REVIEW OF SCIENTIFIC INSTRUMENTS, 1972, 43 (02) :205-&