Evidence that the (6-4) photolyase mechanism can proceed through an oxetane intermediate

被引：18

作者：

Asgatay, Saadia ^{[1
]}

Petermann, Christian ^{[1
]}

Harakat, Dominique ^{[2
]}

Guillaume, Dominique ^{[1
]}

Taylor, John-Stephen ^{[3
]}

Clivio, Pascale ^{[1
]}

机构：

[1] Univ Reims, Inst Chim Mol Reims, UFR Pharm, CNRS,UMR 6229, F-51096 Reims, France

[2] UFR Sci Exactes & Nat, F-51687 Reims 2, France

[3] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 38期

关键词：

D O I：

10.1021/ja805214s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using the analogue of TpT methylated at the 3'-end N(3) position (Tpm(3)T), we demonstrate that when the oxetane/(6-4) pathway is precluded, water addition occurs at the 3'-end C6 position of the oxetane intermediate to provide its opening. Photoreversal of this (6-4) photoproduct C6 hydrate brings the first experimental evidence that the (6-4) photolyase repair can proceed through an oxetane intermediate.

引用

页码：12618 / +

页数：3

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