Protein tyrosine phosphatases

被引：35

作者：

Mustelin, T ^{[1
]}

Feng, GS ^{[1
]}

Bottini, N ^{[1
]}

Alonso, A ^{[1
]}

Kholod, N ^{[1
]}

Birle, D ^{[1
]}

Merlo, J ^{[1
]}

Huynh, H ^{[1
]}

机构：

[1] Burnham Inst, La Jolla Canc Res Ctr, La Jolla, CA 92037 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2002年 / 7卷

关键词：

review; phosphatases; PTPases; HePTP; STEP; PCPTP; PTP1B; TCPTP; SHP1; SHP2; PEP; PTP-PEST; PTP-HSCF; PTP-MEG2; PTPH1; PTP-MEG1; FAP-1; PTP-BAS; PTP36; VHR; Pac-1; MKP-1; MKP-2; MKP-3; MKP-4; MKP-X; B23; hVH4; M3/6; PTEN; LMPTP; PRL-1; OV-1; PRL-2; PRL-3;

D O I：

10.2741/mustelin

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular mechanisms of signal transduction have been at the focus of increasingly intense scientific research. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade. In contrast, the study of protein tyrosine phosphatases has lagged behind, but is now gathering momentum and is predicted to become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the art in our understanding of the structure, regulation and role of protein tyrosine phosphatases with emphasis on the lymphocyte system.

引用

页码：D85 / D142

页数：58

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