Role of transcription factors in commitment and differentiation of early B lymphoid cells

被引：15

作者：

Roessler, S ^{[1
]}

Grosschedl, R ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol, Dept Cellular & Mol Immunol, D-79108 Freiberg, Germany

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 01期

关键词：

Pu.1; Ikaros; E2A; EBF; Pax5;

D O I：

10.1016/j.smim.2005.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted into antibody-producing plasma cells. B cell differentiation involves multiple steps, including cell specification, commitment to the B cell lineage, immunoglobulin rearrangements, maturation of B cells and terminal differentiation into plasma cells. Each of these steps is controlled by signaling pathways and transcription factors that act in synergy. feedback-loops or cross-antagonism to Generate complex regulatory networks that allow for plasticity and stability of B cell differentiation. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：12 / 19

页数：8

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