Why immunomodulatory therapies have not worked in sepsis

[1] EFFICACY AND SAFETY OF MONOCLONAL-ANTIBODY TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH SEPSIS SYNDROME - A RANDOMIZED, CONTROLLED, DOUBLE-BLIND, MULTICENTER CLINICAL-TRIAL [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (12): : 934 - 941

[2] Abraham E, 1998, LANCET, V351, P929

[3] Abraham E, 1997, WESTERN J MED, V166, P195

[4] p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock - A randomized controlled multicenter trial [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (19): : 1531 - 1538

[5] ABRAHAM E, 1998, AM THOR SOC INT C AP

[6] [Anonymous], 1963, JAMA

[7] The effects of ibuprofen on the physiology and survival of patients with sepsis [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (13) : 912 - 918

[8] HIGH-DOSE CORTICOSTEROIDS IN PATIENTS WITH THE ADULT RESPIRATORY-DISTRESS SYNDROME [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (25) : 1565 - 1570

[9] PROSTACYCLIN AND THROMBOXANE-A2 FORMATION IS INCREASED IN HUMAN SEPSIS SYNDROME - EFFECTS OF CYCLOOXYGENASE INHIBITION [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05): : 1095 - 1101

[10] Reversal of late septic shock with supraphysiologic doses of hydrocortisone [J]. CRITICAL CARE MEDICINE, 1998, 26 (04) : 645 - 650

[1] EFFICACY AND SAFETY OF MONOCLONAL-ANTIBODY TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH SEPSIS SYNDROME - A RANDOMIZED, CONTROLLED, DOUBLE-BLIND, MULTICENTER CLINICAL-TRIAL [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (12): : 934 - 941

[2] Abraham E, 1998, LANCET, V351, P929

[3] Abraham E, 1997, WESTERN J MED, V166, P195

[4] p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock - A randomized controlled multicenter trial [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (19): : 1531 - 1538

[5] ABRAHAM E, 1998, AM THOR SOC INT C AP

[6] [Anonymous], 1963, JAMA

[7] The effects of ibuprofen on the physiology and survival of patients with sepsis [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (13) : 912 - 918

[8] HIGH-DOSE CORTICOSTEROIDS IN PATIENTS WITH THE ADULT RESPIRATORY-DISTRESS SYNDROME [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (25) : 1565 - 1570

[9] PROSTACYCLIN AND THROMBOXANE-A2 FORMATION IS INCREASED IN HUMAN SEPSIS SYNDROME - EFFECTS OF CYCLOOXYGENASE INHIBITION [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05): : 1095 - 1101

[10] Reversal of late septic shock with supraphysiologic doses of hydrocortisone [J]. CRITICAL CARE MEDICINE, 1998, 26 (04) : 645 - 650