Why immunomodulatory therapies have not worked in sepsis

[41] Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis [J]. LANCET, 1997, 350 (9089) : 1439 - 1443

[42] ADMINISTRATION OF LOW-DOSE ENDOTOXIN TO HEALTHY HUMANS INCREASES C5A BINDING TO CIRCULATING NEUTROPHILS [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (02) : 480 - 482

[43] A CONTROLLED CLINICAL-TRIAL OF E5 MURINE MONOCLONAL IGM ANTIBODY TO ENDOTOXIN IN THE TREATMENT OF GRAM-NEGATIVE SEPSIS [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (08): : 1097 - 1102

[44] EXPERIMENTAL GRAM-NEGATIVE BACTERIAL SEPSIS - PREVENTION OF MORTALITY NOT PREVENTABLE BY ANTIBIOTICS ALONE [J]. INFECTION AND IMMUNITY, 1979, 25 (02) : 538 - 557

[45] p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E(2) biosynthesis stimulated by interleukin-1 beta [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (12) : 8083 - 8089

[46] Harada A, 1996, MOL MED TODAY, V2, P482

[47] COMPARISON OF PERIPHERAL-BLOOD LEUKOCYTE KINETICS AFTER LIVE ESCHERICHIA-COLI, ENDOTOXIN, OR INTERLEUKIN-1-ALPHA ADMINISTRATION - STUDIES USING A NOVEL INTERLEUKIN-1 RECEPTOR ANTAGONIST [J]. ANNALS OF SURGERY, 1993, 218 (01) : 79 - 90

[48] INTERFERON-GAMMA, A MEDIATOR OF LETHAL LIPOPOLYSACCHARIDE-INDUCED SHWARTZMAN-LIKE SHOCK REACTIONS IN MICE [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (06) : 1853 - 1869

[49] Heumann D, 1998, PROG CLIN BIOL RES, V397, P379

[50] HINSHAW LB, 1985, CIRC SHOCK, V16, P265

[41] Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis [J]. LANCET, 1997, 350 (9089) : 1439 - 1443

[42] ADMINISTRATION OF LOW-DOSE ENDOTOXIN TO HEALTHY HUMANS INCREASES C5A BINDING TO CIRCULATING NEUTROPHILS [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (02) : 480 - 482

[43] A CONTROLLED CLINICAL-TRIAL OF E5 MURINE MONOCLONAL IGM ANTIBODY TO ENDOTOXIN IN THE TREATMENT OF GRAM-NEGATIVE SEPSIS [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (08): : 1097 - 1102

[44] EXPERIMENTAL GRAM-NEGATIVE BACTERIAL SEPSIS - PREVENTION OF MORTALITY NOT PREVENTABLE BY ANTIBIOTICS ALONE [J]. INFECTION AND IMMUNITY, 1979, 25 (02) : 538 - 557

[45] p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E(2) biosynthesis stimulated by interleukin-1 beta [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (12) : 8083 - 8089

[46] Harada A, 1996, MOL MED TODAY, V2, P482

[47] COMPARISON OF PERIPHERAL-BLOOD LEUKOCYTE KINETICS AFTER LIVE ESCHERICHIA-COLI, ENDOTOXIN, OR INTERLEUKIN-1-ALPHA ADMINISTRATION - STUDIES USING A NOVEL INTERLEUKIN-1 RECEPTOR ANTAGONIST [J]. ANNALS OF SURGERY, 1993, 218 (01) : 79 - 90

[48] INTERFERON-GAMMA, A MEDIATOR OF LETHAL LIPOPOLYSACCHARIDE-INDUCED SHWARTZMAN-LIKE SHOCK REACTIONS IN MICE [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (06) : 1853 - 1869

[49] Heumann D, 1998, PROG CLIN BIOL RES, V397, P379

[50] HINSHAW LB, 1985, CIRC SHOCK, V16, P265