Protein profiling as a diagnostic tool in clinical chemistry: a review

被引：35

作者：

Bons, JAP ^{[1
]}

Wodzig, WKWH ^{[1
]}

van Dieijen-Visser, MP ^{[1
]}

机构：

[1] Univ Hosp Maastricht, Dept Clin Chem, NL-6229 HX Maastricht, Netherlands

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2005年 / 43卷 / 12期

关键词：

biomarker; decision tree; diagnostic value; ovarian cancer; post-analytical conditions; pre-analytical conditions; prostate cancer; protein profiling; proteomics; surface-enhanced laser desorption/ionization time-of-flight mass spectrometry;

D O I：

10.1515/CCLM.2005.222

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) appears to be an important diagnostic tool for a whole range of diseases. Sensitivities and specificities obtained with this new technology often seem superior to those obtained with current biomarkers. However, reproducibility and standardization are still problematic. The present review gives an overview of the diagnostic value of protein profiles obtained with SELDI in studies on prostate and ovarian cancer. To identify aspects important for protein profiling, we compare and discuss differences in pre- and post-analytical conditions presented in the literature supplemented with some of our own data. Further progress in protein profiling as a diagnostic tool requires a more comprehensive description of technical details in all future studies.

引用

页码：1281 / 1290

页数：10

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