A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer

被引:63
作者
Adjei, AA [1 ]
机构
[1] Mayo Clin, Div Med Oncol, Rochester, MN 55905 USA
关键词
chemotherapy; colorectal cancer; new agents;
D O I
10.1046/j.1365-2125.1999.00010.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Colorectal carcinoma is an important cause of cancer morbidity and mortality. 5-fluorouracil has been the major chemotherapeutic agent for the treatment of colorectal carcinoma for the past four decades. This regimen is noncurative, and its impact on survival is unclear. Attempts at identifying more effective chemotherapeutic agents for colorectal cancer have yielded oral formulations and prodrugs of 5-fluorouracil with apparently equivalent efficacy. Specific thymidylate synthase inhibitors are now available. Platinum analogues with activity in colorectal carcinoma, and no cross-resistance to the antimetabolites have also been developed. The topoisomerase I inhibitors represent a new class of agents with a novel mechanism of action. These agents are in phase II and Phase III clinical trials, others have been approved for clinical use within the last 3 years.
引用
收藏
页码:265 / 277
页数:13
相关论文
共 102 条
  • [81] SALTZ L, 1995, P AN M AM SOC CLIN, V14, pA1546
  • [82] SALTZ LB, 1995, CANCER, V75, P782, DOI 10.1002/1097-0142(19950201)75:3<782::AID-CNCR2820750306>3.0.CO
  • [83] 2-I
  • [84] SANCHIZ F, 1994, JPN J CLIN ONCOL, V24, P322
  • [85] SCHILSKY RL, 1996, P AN M AM SOC CLIN, V15, P485
  • [86] SCHILSKY RL, 1992, CHEMOTHERAPY SOURCE, P301
  • [87] SCHULTZ R, 1996, ANN ONCOL S1, V7, P85
  • [88] PHASE-I-II TRIAL OF DOXIFLURIDINE (5'DFUR) ADMINISTERED AS LONG-TERM CONTINUOUS INFUSION USING A PORTABLE INFUSION PUMP FOR ADVANCED COLORECTAL-CANCER
    SCHUSTER, D
    HEIM, ME
    DECOSTER, G
    QUEISSER, W
    [J]. EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1989, 25 (11): : 1543 - 1548
  • [89] SHIH C, 1996, ANN ONCOL S1, V7, P85
  • [90] PHASE-II STUDY OF CPT-11, A NEW CAMPTOTHECIN DERIVATIVE, IN METASTATIC COLORECTAL-CANCER
    SHIMADA, Y
    YOSHINO, M
    WAKUI, A
    NAKAO, I
    FUTATSUKI, K
    SAKATA, Y
    KAMBE, M
    TAGUCHI, T
    OGAWA, N
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (05) : 909 - 913