Plasma and liver carnitine status of children with chronic liver disease and cirrhosis

被引:17
作者
Selimoglu, MA [1 ]
Aydogdu, S [1 ]
Yagci, RV [1 ]
Huseyinov, A [1 ]
机构
[1] Ege Univ, Dept Pediat Gastroenterol & Nutr, Izmir, Turkey
关键词
carnitine; cirrhosis; liver; plasma; Wilson's disease;
D O I
10.1046/j.1442-200X.2001.01423.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Carnitine is an essential cofactor in the transfer of long-chain fatty acids across the inner mitochondrial membrane for oxidation. As its synthesis is performed in the liver, alterations in carnitine metabolism is expected in liver diseases, especially in cirrhosis. Methods: In this study, we investigated plasma and liver carnitine concentrations of 68 children with chronic liver disease, 36 of whom had cirrhosis as well. Carnitine level was determined by enzymatic method. Results: Plasma and liver carnitine concentrations were not correlated. Mean plasma carnitine level of cirrhotic children was significantly lower than that of the control group (P < 0.0001). While there was no difference between liver carnitine concentrations of children with chronic liver disease and cirrhosis (P > 0.05), mean plasma level of cirrhotics were lower (P < 0.05). Plasma carnitine was correlated with albumin, triglyceride and gamma glutamyl transpeptidase (GGT) in patients with chronic liver disease (P < 0.05). Liver carnitine was correlated with GGT in cirrhotic patients (P < 0.005). Children with malnutrition had higher plasma and liver carnitine levels (P < 0.05). The highest plasma and liver carnitine levels were detected in children with biliary atresia and criptogenic cirrhosis, respectively. Both the lowest plasma and liver carnitine levels were detected in Wilson's disease. Conclusion: Children with cirrhosis have low plasma carnitine concentrations. This finding is prominent in children with Wilson's disease. As carnitine is an essential factor in lipid metabolism, the carnitine supplementation for patients with cirrhosis in childhood, especially with Wilson's disease, seems to be mandatory.
引用
收藏
页码:391 / 395
页数:5
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