Decreased nitric oxide production in primary open-angle glaucoma

被引:69
作者
Doganay, S
Evereklioglu, C
Turkoz, Y
Er, H
机构
[1] Inonu Univ, Fac Med,Res Hosp, Turgut Ozal Med Ctr, Dept Ophthalmol, Malatya, Turkey
[2] Inonu Univ, Fac Med,Res Hosp, Turgut Ozal Med Ctr, Dept Biochem, Malatya, Turkey
关键词
nitric oxide; aqueous humor; glaucoma;
D O I
10.1177/112067210201200109
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE. Raised intraocular pressure (IOP) is the major risk factor responsible for optic nerve damage in primary open-angle glaucoma (POAG). The trabecular meshwork acts as a valve in aqueous outflow and relaxes with nitric oxide (NO) agonists. Since NO is synthesized by endothelium and smooth muscle elsewhere in the body, this study investigated the NO levels in the aqueous humor of patients with POAG compared with cataract patients. MATERIALS AND METHODS. Aqueous humor samples were taken by paracentesis from 16 consecutive patients with POAG (9 male and 7 female; mean age 69.0 +/- 3.4 yrs) and 14 age and sex-matched controls with cataract (8 male and 6 female; mean age 66.7 +/- 4.1 yrs) during elective surgery. As an indicator for NO, aqueous total nitrite levels (end - product of NO) were measured by Greiss reaction. The Mann-Whitney U test was used for statistical analysis and P <0.05 was considered significant. RESULTS. The mean age and sex in two groups were comparable. The mean aqueous humor NO levels were significantly (P = 0.001) lower in patients with glaucoma (72.72 +/- 11.21 mumol/L) than in patients with cataract and no glaucoma (86.92 +/- 11.23 mumol/L). CONCLUSIONS. Decreased NO production in patients with POAG indicates that NO-producing cells may be lost as the disease progresses. The control of NO levels in the eye might be a therapeutic target in glaucoma.
引用
收藏
页码:44 / 48
页数:5
相关论文
共 18 条
[11]  
NATHANSON JA, 1995, INVEST OPHTH VIS SCI, V36, P1765
[12]   Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract [J].
Noske, W ;
Hensen, J ;
Wiederholt, M .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1997, 235 (09) :551-552
[13]  
OCHOA JB, 1991, ANN SURG, V214, P612
[14]   Increased nitric oxide production in the spermatic vein of patients with varicocele [J].
Ozbek, E ;
Turkoz, Y ;
Gokdeniz, R ;
Davarci, M ;
Ozugurlu, F .
EUROPEAN UROLOGY, 2000, 37 (02) :172-175
[15]   VASCULAR ENDOTHELIAL-CELLS SYNTHESIZE NITRIC-OXIDE FROM L-ARGININE [J].
PALMER, RMJ ;
ASHTON, DS ;
MONCADA, S .
NATURE, 1988, 333 (6174) :664-666
[16]  
Veszelovszky E, 1995, CANCER CHEMOTH PHARM, V36, P155
[17]   REGULATION OF OUTFLOW RATE AND RESISTANCE IN THE PERFUSED ANTERIOR SEGMENT OF THE BOVINE EYE [J].
WIEDERHOLT, M ;
BIELKA, S ;
SCHWEIG, F ;
LUTJENDRECOLL, E ;
LEPPLEWIENHUES, A .
EXPERIMENTAL EYE RESEARCH, 1995, 61 (02) :223-234
[18]   Aqueous humor nitric oxide levels in patients with central retinal artery occlusion [J].
Yilmaz, G ;
Acar, MA ;
Gazyagci, S ;
Duman, S ;
Aydin, P .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2000, 20 (06) :610-613