Rates of growth and loss of bone mineral in the spine and femoral neck in white females

被引:46
作者
Hui, SL
Zhou, L
Evans, R
Slemenda, CW
Peacock, M
Weaver, CM
McClintock, C
Johnston, CC
机构
[1] Regenstrief Inst Hlth Care, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA
[3] Indiana Univ, Ctr Aging Res, Indianapolis, IN 46204 USA
[4] Purdue Univ, Dept Nutr, W Lafayette, IN 47907 USA
关键词
age-specific rates; bone mineral density; longitudinal studies;
D O I
10.1007/s001980050137
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study characterizes the rates of growth and loss of bone mass as a function of age in white females. It combines longitudinal data from several studies of bone mass on healthy white female subjects ranging from age 6 to 90 years. Rates of change in bone area, bone mineral content (BMC) and bone mineral density (BMD) are estimated separately for the spine and the femoral neck of each individual using linear regression. The individual rates of change are then fitted as a nonparametric function of age using weighted moving averages, resulting in a curve of age-specific mean change as a function of age. When the curves of BMD were compared between the hip and the femoral neck, the cessation of bone growth and the onset of bone loss were found to occur at an earlier age at the hip than at the spine. No significant differences in the ages of maximum rates of growth or maximum loss were found between the two skeletal sites. This information will be useful for designing interventions to promote bone growth or retard bone loss.
引用
收藏
页码:200 / 205
页数:6
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