Genetic Susceptibility to Rheumatoid Arthritis: An Emerging Picture

被引：70

作者：

Barton, Anne ^{[1
]}

Worthington, Jane ^{[1
]}

机构：

[1] Univ Manchester, Epidemiol Unit, Manchester, Lancs, England

来源：

ARTHRITIS CARE & RESEARCH | 2009年 / 61卷 / 10期

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISM; LYMPHOID TYROSINE PHOSPHATASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL HAPLOTYPE; PTPN22; GENE; RISK-FACTOR; STAT4; ASSOCIATION; PADI4; VARIANTS;

D O I：

10.1002/art.24672

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

At least 13 loci have now been confidently confirmed as being associated with RA susceptibility, and further insights into the genetic contribution to disease are likely to be revealed in the next 12 months. From the genes identified to date, it is clear that immune dysregulation plays a key role in susceptibility to RA, and that variation in the same loci may predispose to other autoimmune diseases. Although there are some inflammatory arthritis-specific genes, the majority do not show exclusive association with RA; therefore, it remains unclear as to what determines the pattern, extent, and progression of disease.

引用

页码：1441 / 1446

页数：6

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