Genetic Susceptibility to Rheumatoid Arthritis: An Emerging Picture

被引：70

作者：

Barton, Anne ^{[1
]}

Worthington, Jane ^{[1
]}

机构：

[1] Univ Manchester, Epidemiol Unit, Manchester, Lancs, England

来源：

ARTHRITIS CARE & RESEARCH | 2009年 / 61卷 / 10期

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISM; LYMPHOID TYROSINE PHOSPHATASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL HAPLOTYPE; PTPN22; GENE; RISK-FACTOR; STAT4; ASSOCIATION; PADI4; VARIANTS;

D O I：

10.1002/art.24672

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

At least 13 loci have now been confidently confirmed as being associated with RA susceptibility, and further insights into the genetic contribution to disease are likely to be revealed in the next 12 months. From the genes identified to date, it is clear that immune dysregulation plays a key role in susceptibility to RA, and that variation in the same loci may predispose to other autoimmune diseases. Although there are some inflammatory arthritis-specific genes, the majority do not show exclusive association with RA; therefore, it remains unclear as to what determines the pattern, extent, and progression of disease.

引用

页码：1441 / 1446

页数：6

共 65 条

[31] Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma [J].

Majorczyk, Edyta ;

Jasek, Monika ;

Ploski, Rafal ;

Wagner, Marta ;

Kosior, Anna ;

Pawlik, Andrzej ;

Obojski, Andrzej ;

Luszczek, Wioleta ;

Nowak, Izabela ;

Wisniewski, Andrzej ;

Kusnierczyk, Piotr .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2007, 15 (10) :1043-1048

[32] Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases [J].

Martinez, A. ;

Varade, J. ;

Marquez, A. ;

Cenit, M. C. ;

Espino, L. ;

Perdigones, N. ;

Santiago, J. L. ;

Fernandez-Arquero, M. ;

de la Calle, H. ;

Arroyo, R. ;

Mendoza, J. L. ;

Fernandez-Gutierrez, B. ;

de la Concha, E. G. ;

Urcelay, E. .

ARTHRITIS AND RHEUMATISM, 2008, 58 (09) :2598-2602

[33]

Mastana S, 2007, J RHEUMATOL, V34, P1984

[34] Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene [J].

Michou, Laetitia ;

Lasbleiz, Sandra ;

Rat, Anne-Christine ;

Migliorini, Paola ;

Balsa, Alejandro ;

Westhovens, Ren ;

Barrera, Pilar ;

Alves, Helena ;

Pierlot, Celine ;

Glikmans, Elodie ;

Garnier, Sophie ;

Dausset, Jean ;

Vaz, Carlos ;

Fernandes, Manuela ;

Petit-Teixeira, Elisabeth ;

Lemaire, Isabelle ;

Pascual-Salcedo, Dora ;

Bombardieri, Stefano ;

Dequeker, Jan ;

Radstake, Timothy R. ;

Van Riel, Piet ;

van de Putte, Leo ;

Lopes-Vaz, Antonio ;

Prum, Bernard ;

Bardin, Thomas ;

Dieude, Philippe ;

Cornelis, Francois .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (05) :1649-1654

[35] Ethnic differences in allele frequency of autoimmune-disease-associated SNPs [J].

Mori, M ;

Yamada, R ;

Kobayashi, K ;

Kawaida, R ;

Yamamoto, K .

JOURNAL OF HUMAN GENETICS, 2005, 50 (05) :264-266

[36] The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome [J].

Naseem, H. ;

Thomson, W. ;

Silman, A. ;

Worthington, J. ;

Symmons, D. ;

Barton, A. .

ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (02) :251-255

[37] A review of the MHC genetics of rheumatoid arthritis [J].

Newton, JL ;

Harney, SMJ ;

Wordsworth, BP ;

Brown, MA .

GENES AND IMMUNITY, 2004, 5 (03) :151-157

[38] Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus [J].

Orozco, G ;

Sánchez, E ;

González-Gay, MA ;

López-Nevot, MA ;

Torres, B ;

Cáliz, R ;

Ortego-Centeno, N ;

Jiménez-Alonso, J ;

Pascual-Salcedo, D ;

Balsa, A ;

de Pablo, R ;

Nuñez-Roldan, A ;

González-Escribano, MF ;

Martín, J .

ARTHRITIS AND RHEUMATISM, 2005, 52 (01) :219-224

[39]

OROZCO G, 2009, ANN RHEUM DIS

[40] Association of STAT4 with rheumatoid arthritis -: A replication study in three European populations [J].

Orozco, Gisela ;

Alizadeh, Behrooz Z. ;

Delgado-Vega, Angelica M. ;

Gonzalez-Gay, Miguel A. ;

Balsa, Alejandro ;

Pascual-Salcedo, Dora ;

Fernandez-Gutierrez, Benjamin ;

Gonzalez-Escribano, Maria F. ;

Petersson, Ingemar F. ;

van Riel, Piet L. C. M. ;

Barrera, Pilar ;

Coenen, Marieke J. H. ;

Radstake, Timothy R. D. J. ;

van Leeuwen, Miek A. ;

Wijmenga, Cisca ;

Koeleman, Bobby P. C. ;

Alarcon-Riquelme, Marta ;

Martin, Javier .

ARTHRITIS AND RHEUMATISM, 2008, 58 (07) :1974-1980

← 1 2 3 4 5 6 7 →