Phosphoinositide 3-kinases in immunity: Lessons from knockout mice

被引：44

作者：

Sasaki, T

Suzuki, A

Sasaki, J

Penninger, JM

机构：

[1] Tokyo Metropolitan Inst Med Sci, Dept Pharmacol, Bunkyo Ku, Tokyo 1138613, Japan

[2] Japan Sci & Technol Corp, PRESTO, Akita 0108543, Japan

[3] Akita Univ, Sch Med, Dept Biochem, Akita 0108543, Japan

[4] Univ Toronto, Dept Med Biophys & Immunol, Toronto, ON M5G 2C1, Canada

[5] Austrian Acad Sci, Inst Mol Biotech, A-1030 Vienna, Austria

来源：

JOURNAL OF BIOCHEMISTRY | 2002年 / 131卷 / 04期

关键词：

immune system; knockout mouse; lipid signaling; phosphoinositide; 3-kinase; phosphoinositide phosphatases;

D O I：

10.1093/oxfordjournals.jbchem.a003126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphoinositide 3-kinases (PI3Ks) constitute a family of evolutionarily conserved lipid kinases that phosphorylate the D3 position of the inositol ring of phosphoinositides and produce PI(3)P, PI(3,4)P-2, and PI(3,4,5)P-3. Intense in vitro research over the last decade has unequivocally demonstrated that PI3Ks, in particular those belonging to class 1, regulate a vast array of fundamental cellular responses. Given the pleiotropic roles of PI3Ks and the lipid product PI(3,4,5)P-3 in plethora of cellular responses, it is pertinent to explore the significance of PI3K signaling in vivo. In the past two or three years, the components of this signaling pathway have been genetically manipulated in mouse. This review briefly summarizes the immunological significance of PI3K signaling as revealed by the study of gene-targeted "knockout" mice.

引用

页码：495 / 501

页数：7

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