Phylogeographic analysis of haplogroup E3b (E-M215) Y chromosomes reveals multiple migratory events within and out of Africa

被引:156
作者
Cruciani, F
La Fratta, R
Santolamazza, P
Sellitto, D
Pascone, R
Moral, P
Watson, E
Guida, V
Colomb, EB
Zaharova, B
Lavinha, J
Vona, G
Aman, R
Calì, F
Akar, N
Richards, M
Torroni, A
Novelletto, A
Scozzari, R
机构
[1] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Sci Ginecol Perinatol & Puericultura, Rome, Italy
[3] CNR, Ist Biol & Patol Mol, Rome, Italy
[4] Ist Casa Sollievo Sofferenza Mendel, Rome, Italy
[5] Univ Barcelona, Dept Anim Biol, Barcelona, Spain
[6] Swedish Museum Nat Hist, S-10405 Stockholm, Sweden
[7] Hop St Marguerite, Immunol Lab, Marseille, France
[8] Univ Hosp Obstet & Gynecol, Lab Mol Pathol, Sofia, Bulgaria
[9] Inst Nacl Saude Dr Ricardo Jorge, Ctr Genet Humana, Lisbon, Portugal
[10] Univ Cagliari, Dipartimento Biol Sperimentale, Cagliari, Italy
[11] Natl Museums Kenya, Dept Mol Genet, Nairobi, Kenya
[12] African Ctr Clin Trials, Nairobi, Kenya
[13] Assoc Oasi Maria SS, Ist Ric Ritardo Mentale & Involuz Cerebrale, Troina, Italy
[14] Ankara Univ, Dept Pediat, TR-06100 Ankara, Turkey
[15] Univ Leeds, Sch Biol, Leeds, W Yorkshire, England
[16] Univ Leeds, Sch Comp, Leeds, W Yorkshire, England
[17] Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy
[18] Univ Calabria, Dipartimento Biol Cellulare, Arcavacata Di Rende, Italy
关键词
D O I
10.1086/386294
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We explored the phylogeography of human Y-chromosomal haplogroup E3b by analyzing 3,401 individuals from five continents. Our data refine the phylogeny of the entire haplogroup, which appears as a collection of lineages with very different evolutionary histories, and reveal signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25,000 years. In Europe, the overall frequency pattern of haplogroup E-M78 does not support the hypothesis of a uniform spread of people from a single parental Near Eastern population. The distribution of E-M81 chromosomes in Africa closely matches the present area of distribution of Berber-speaking populations on the continent, suggesting a close haplogroup-ethnic group parallelism. E-M34 chromosomes were more likely introduced in Ethiopia from the Near East. In conclusion, the present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny.
引用
收藏
页码:1014 / 1022
页数:9
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