Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

被引：522

作者：

Tong, Qingchun ^{[1
,2
]}

Ye, Chian-Ping ^{[1
,2
]}

Jones, Juli E. ^{[1
,2
]}

Elmquist, Joel K. ^{[3
,4
]}

Lowell, Bradford B. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Endocrinol, Dept Med, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02215 USA

[3] Univ Texas SW Med Ctr Dallas, Div Hypothalam Res, Dept Internal Med, Dallas, TX 75390 USA

[4] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn.2167

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

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收藏

页码：998 / 1000

页数：3

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