Systems pharmacology of complex diseases

被引：11

作者：

Hansen, Jens ^{[1
]}

Zhao, Shan ^{[1
]}

Iyengar, Ravi ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Pharmacol & Syst Therapeut & Syst Biol Ctr, New York, NY 10029 USA

来源：

ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY | 2011年 / 1245卷

关键词：

systems pharmacology; network biology; personalized medicine; TARGETS;

D O I：

10.1111/j.1749-6632.2011.06382.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Systems pharmacology approaches can be used to identify and predict drug-induced adverse events. Disease-centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.

引用

页码：E1 / E5

页数：5

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