Biaryl Formation Involving Carbon-Based Leaving Groups: Why Not?

被引：53

作者：

Bonesi, Sergio M. ^{[1
]}

Fagnoni, Maurizio ^{[2
]}

Albini, Angelo ^{[2
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, CIHIDECAR CONICET, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Pavia, Dept Organ Chem, I-27100 Pavia, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 52期

关键词：

arylation; biphenyls; C-C activation; C-C coupling; leaving groups;

D O I：

10.1002/anie.200803777

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) No loss, no gain: In the synthesis of biaryls either the electrophilic or nucleophilic partner can be replaced by a substrate with a carbon-based leaving group (see scheme). Whereas replacing the electrophilic unit is not worthwhile, the use of nucleophiles with a C-based leaving group has decisive advantages. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：10022 / 10025

页数：4

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