Selective palladium-catalysed ipso arylation of α,α-disubstituted benzo[b]thien-2-ylmethanols with aryl bromides using PCy3 as ligand

被引：30

作者：

Biro, A. Beatrix ^{[1
]}

Kotschy, Andras ^{[1
]}

机构：

[1] Eotvos Lorand Univ, Inst Chem, H-1117 Budapest, Hungary

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 08期

关键词：

benzothiophenes; cross-coupling; palladium; ipso coupling;

D O I：

10.1002/ejoc.200600929

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,alpha-Diphenylbenzo[b]thien-2-ylmethanoI was treated with a series of aryl bromides in the presence of palladium(II) acetate and tricyclohexylphosphane to give the appropriate 2-aryl-benzo[b]thiophenes in good to excellent yield with concomitant formation of benzophenone. The reaction was successfully extended to alpha,alpha-diphenylbenzo[b]thien-3-ylmethanol, although in certain cases the transformation was biased by concurrent ortho arylation. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).

引用

页码：1364 / 1368

页数：5

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