Palladium-catalyzed arylation of ketone enolates:: An expeditious entry to tamoxifen-related 1,2,2-triarylethanones

被引：51

作者：

Churruca, F

SanMartin, R

Tellitu, I

Domínguez, E

机构：

[1] Kimika Organikoa II Saila, Zientzi Fakultatea, Euskal Herriko Unibertsitatea, P.O. Box 644

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 09期

关键词：

D O I：

10.1021/ol025811h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

After a rigorous study on the effect of several catalytic systems, a simple, high yielding procedure for the preparation of 1,2,2-triarylethanones, skeletal analogues of tamoxifen, is presented. Apart from the economic and environmental advantages involved, this palladium-catalyzed arylation of deoxybenzoin enolates features a lack of ortho-arylation side reactions. In addition, an alternative approach from acetophenones to the target triarylethanone system is also announced.

引用

页码：1591 / 1594

页数：4

共 41 条

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