Palladium-catalyzed arylation of ketone enolates:: An expeditious entry to tamoxifen-related 1,2,2-triarylethanones

被引:51
作者
Churruca, F
SanMartin, R
Tellitu, I
Domínguez, E
机构
[1] Kimika Organikoa II Saila, Zientzi Fakultatea, Euskal Herriko Unibertsitatea, P.O. Box 644
关键词
D O I
10.1021/ol025811h
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
After a rigorous study on the effect of several catalytic systems, a simple, high yielding procedure for the preparation of 1,2,2-triarylethanones, skeletal analogues of tamoxifen, is presented. Apart from the economic and environmental advantages involved, this palladium-catalyzed arylation of deoxybenzoin enolates features a lack of ortho-arylation side reactions. In addition, an alternative approach from acetophenones to the target triarylethanone system is also announced.
引用
收藏
页码:1591 / 1594
页数:4
相关论文
共 41 条