Synthesis of lipidic tamoxifen

被引：4

作者：

Lashley, MR ^{[1
]}

Nantz, MH ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(00)00421-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3295 / 3298

页数：4

共 25 条

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