Synthesis of lipidic tamoxifen

被引:4
作者
Lashley, MR [1 ]
Nantz, MH [1 ]
机构
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
关键词
D O I
10.1016/S0040-4039(00)00421-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3295 / 3298
页数:4
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