New generation dopaminergic agents.: 7.: Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template

被引：11

作者：

Mewshaw, RE

Nelson, JA

Shah, US

Shi, XJ

Mazandarani, H

Coupet, J

Marquis, K

Brennan, JA

Andree, TH

机构：

[1] Wyeth Ayerst Res Labs, Goobal Chem Sci Dept, Princeton, NJ 08543 USA

[2] Wyeth Ayerst Res Labs, CNS Disorders Dept, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(99)00434-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of several bioisosteric analogs based on the 3-OH-phenoxyethylamine dopamine D-2 agonist template (i.e., 3) is described. The benzimidazol-2-ones and benzthioimidazol-2-ones (7-10) and 2-trifluoromethyl-benzimidazole (13) were observed to have excellent affinity for the Dp receptor. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2593 / 2598

页数：6

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