Cobalt-mediated cycloisomerization of δ-substituted ε-acetylenic β-ketoesters construction of angular triquinane by a sequence ene/Pauson-Khand reactions

被引：54

作者：

Renaud, JL ^{[1
]}

Aubert, C ^{[1
]}

Malacria, M ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, Lab Chim Organ Synth, F-75252 Paris 05, France

来源：

TETRAHEDRON | 1999年 / 55卷 / 16期

关键词：

cobalt and compounds; ene reaction; 1,4 diastereoselection; Pauson-Khand reaction;

D O I：

10.1016/S0040-4020(99)00172-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of delta-substituted epsilon-acetylenic beta-ketoesters is fully described. Their cobalt-mediated Conia-ene reactions led to variously functionalized methylenecyclopentanes in high yields and with a moderate control of the 1,4 diastereoselectivity. A sequence involving the cobalt-mediated ene and Pauson-Khand reactions is presented and allowed the construction of the angular triquinane framework. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5113 / 5128

页数：16

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