Inhibition of replication of rinderpest virus by 5-fluorouracil

被引:14
作者
Ghosh, A [1 ]
Nayak, R [1 ]
Shaila, MS [1 ]
机构
[1] INDIAN INST SCI,DEPT MICROBIOL & CELL BIOL,BANGALORE 560012,KARNATAKA,INDIA
关键词
rinderpest virus; 5-fluorouracil; virus transcription; antiviral drug;
D O I
10.1016/0166-3542(96)00943-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
5-Fluorouracil (5FU), an analogue of uracil, was found to inhibit the production of infectious particles of rinderpest virus (RPV) in Vero cells (African green monkey kidney cells) by 99%; at a concentration of 1 mu g/ml. The levels of individual mRNA specific for five of the virus genes were also reduced drastically, while the level of mRNA for a cellular housekeeping gene-glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-was unaltered by fluorouracil treatment of infected cells. Both virus RNA and protein synthesis showed inhibition in a dose-dependent manner. The virions which budded out of 5-fluorouracil-treated cells also contained reduced amounts of virus proteins compared with virus particles from untreated cells.
引用
收藏
页码:35 / 44
页数:10
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