Degradation pathway of carboplatin in aqueous solution

被引：17

作者：

Pujol, M

Girona, V

Prat, J

Munoz, M

DeBolos, J

机构：

[1] Unitat de Fisico-Quimica, Facultad de Farmacia, Universitat de Barcelona, 08028 Barcelona, Argda Joan XXIII s n

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 146卷 / 02期

关键词：

carboplatin; cisplatin; cytostatic platinum complexes; HPLC;

D O I：

10.1016/S0378-5173(96)04788-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A degradation pathway for carboplatin in aqueous solution is described. Degraded solutions of carboplatin in water and in 5% glucose solution were analysed by high performance liquid chromatography; carboplatin and its degradation products were well separated. Three degradation products of carboplatin have been determined either in pure water and 5% glucose solution and they have been identified as 1,1-cyclobutanedicarboxilate anion, its protonated forms and cis-diamminediaquoplatinum (II) complex. (C) 1997 Elsevier Science B.V.

引用

页码：263 / 269

页数：7

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