An actin-myosin complex on actively transcribing genes

被引：150

作者：

Fomproix, N ^{[1
]}

Percipalle, P ^{[1
]}

机构：

[1] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 2004年 / 294卷 / 01期

关键词：

actin-myosin complex; RNA polymerase I; ribosomal genes; intranuclear motors; transcription; RNA elongation;

D O I：

10.1016/j.yexcr.2003.10.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Actin and myosin have been individually implicated in different aspects of gene expression. Here, we show in vivo evidence for a specific nucleolar actin-myosin complex physically associated with both the RNA polymerase I holoenzyme and ribosomal genes. We find that this specific actin-myosin complex is functionally coupled to elongating ribosomal RNA transcripts in living cells. From these observations, we conclude that an actin-based myosin motor is associated with transcribing ribosomal genes in the cell nucleus. These results correlate with an involvement of both actin and myosin in regulating mRNA synthesis and suggest that actin-myosin motors may provide a general mechanism to facilitate elongation of RNA transcripts during transcription of both ribosomal genes and protein-coding genes. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：140 / 148

页数：9

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