Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists

被引：50

作者：

Bergmeier, SC

Lapinsky, DJ

Free, RB

McKay, DB

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Ohio State Univ, Coll Pharm, Div Pharmacol, Columbus, OH 43210 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(99)00378-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have prepared ring E analogs of the diterpenoid alkaloid methyllycaconitine. These compounds have been assayed for nicotinic activity and were found to act as functional antagonists on adrenal nicotinic receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2263 / 2266

页数：4

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