Emotional impairment in Parkinson's disease

被引：22

作者：

Kawamura, Mitsuru ^{[1
,2
]}

Kobayakawa, Mutsutaka

机构：

[1] Showa Univ, Sch Med, Dept Neurol, Shinagawa Ku, Tokyo 1428666, Japan

[2] Japan Sci & Technol Agcy, CREST, Saitama, Japan

来源：

PARKINSONISM & RELATED DISORDERS | 2009年 / 15卷

基金：

日本学术振兴会;

关键词：

Parkinson's disease; Emotion; Amygdala; FACIAL EXPRESSION RECOGNITION; POSITRON-EMISSION-TOMOGRAPHY; DIPOLE TRACING METHOD; DECISION-MAKING; ORBITOFRONTAL CORTEX; JUVENILE PARKINSONISM; COGNITIVE IMPAIRMENT; PREFRONTAL CORTEX; BASAL GANGLIA; HUMAN BRAIN;

D O I：

10.1016/S1353-8020(09)70013-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Patients with Parkinson's disease (PD) may show emotional impairment in the early stages of the disease. PD patients show disadvantageous decision-making. which is related to decreased emotional responses, its measured by skin conductance responses (SCRs). This pattern of decreasing SCRs is similar to that observed in amygdala-damaged patients. In facial expression recognition, PD patients did not show amygdala activation. In another study, PD patients did not show amygdala activations to unpleasant olfactory Stimuli, which were observed in normal controls. Emotional impairment in PD patients may reflect amygdala dysfunction in early PD. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：S47 / S52

页数：6

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