Integration of chemosensory pathways in the Drosophila second-order olfactory centers

被引:205
作者
Tanaka, NK
Awasaki, T
Shimada, T
Ito, K [1 ]
机构
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[2] Grad Univ Adv Studies, Okazaki, Aichi 4448585, Japan
[3] Natl Inst Basic Biol, Okazaki, Aichi 4448585, Japan
[4] Univ Tokyo, Inst Mol & Cellular Biosci, Japan Sci & Technol Agcy, Inst Bioinformat Res & Dev,Bunkyo Ku, Tokyo 1130032, Japan
基金
日本科学技术振兴机构;
关键词
D O I
10.1016/j.cub.2004.03.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Behavioral responses to odorants require neurons of the higher olfactory centers to integrate signals detected by different chemosensory neurons. Recent studies revealed stereotypic arborizations of second-order olfactory neurons from the primary olfactory center to the secondary centers, but how third-order neurons read this odor map remained unknown. Results: Using the Drosophila brain as a model system, we analyzed the connectivity patterns between second-order and third-order olfactory neurons. We first isolated three common projection zones in the two secondary centers, the mushroom body (MB) and the lateral horn (LH). Each zone receives converged information via second-order neurons from particular subgroups of antennal-lobe glomeruli. In the MB, third-order neurons extend their dendrites across various combinations of these zones, and axons of this heterogeneous population of neurons converge in the output region of the MB. In contrast, arborizations of the third-order neurons in the LH are constrained within a zone. Moreover, different zones of the LH are linked with different brain areas and form preferential associations between distinct subsets of antennal-lobe glomeruli and higher brain regions. Conclusions: MB is known to be an indispensable site for olfactory learning and memory, whereas LH function is reported to be sufficient for mediating direct nonassociative responses to odors. The structural organization of second-order and third-order neurons suggests that MB is capable of integrating a wide range of odorant information across glomeruli, whereas relatively little integration between different subsets of the olfactory signal repertoire is likely to occur in the LH.
引用
收藏
页码:449 / 457
页数:9
相关论文
共 49 条
[11]   DROSOPHILA MUSHROOM BODY MUTANTS ARE DEFICIENT IN OLFACTORY LEARNING [J].
HEISENBERG, M ;
BORST, A ;
WAGNER, S ;
BYERS, D .
JOURNAL OF NEUROGENETICS, 1985, 2 (01) :1-30
[12]   Mushroom body memoir: From maps to models [J].
Heisenberg, M .
NATURE REVIEWS NEUROSCIENCE, 2003, 4 (04) :266-275
[13]   Mechanisms of olfactory discrimination: Converging evidence for common principles across phyla [J].
Hildebrand, JG ;
Shepherd, GM .
ANNUAL REVIEW OF NEUROSCIENCE, 1997, 20 :595-631
[14]   DISTRIBUTION, CLASSIFICATION, AND DEVELOPMENT OF DROSOPHILA GLIAL-CELLS IN THE LATE EMBRYONIC AND EARLY LARVAL VENTRAL NERVE CORD [J].
ITO, K ;
URBAN, J ;
TECHNAU, GM .
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1995, 204 (05) :284-307
[15]  
Ito K, 1997, DEVELOPMENT, V124, P761
[16]   Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies [J].
Jefferis, GSXE ;
Marin, EC ;
Watts, RJ ;
Luo, LQ .
CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (01) :80-86
[17]   Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulb [J].
Kashiwadani, H ;
Sasaki, YF ;
Uchida, N ;
Mori, K .
JOURNAL OF NEUROPHYSIOLOGY, 1999, 82 (04) :1786-1792
[18]   Mushroom bodies are not required for courtship behavior by normal and sexually mosaic Drosophila [J].
Kido, A ;
Ito, K .
JOURNAL OF NEUROBIOLOGY, 2002, 52 (04) :302-311
[19]   Olfactory maps and odor images [J].
Korsching, S .
CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (04) :387-392
[20]  
Laissue PP, 1999, J COMP NEUROL, V405, P543