Regulation of the hypothalamo-pituitary-adrenal axis by cytokines

被引：46

作者：

Mulla, A ^{[1
]}

Buckingham, JC ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Sch Med, Dept Neuroendocrinol, London W6 8RF, England

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 1999年 / 13卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

glucocorticoids; hypothalamo-pituitary-adrenocortical axis; stress; neuroendocrine-immune communication; cytokines; interleukins; 1; and; 6; tumour necrosis factor-alpha; eicosanoids;

D O I：

10.1053/beem.1999.0041

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Many of the pro-inflammatory cytokines which are released in response to immune/ inflammatory insults exert marked stimulatory influences on the hypothalamo-pituitary-adrenocortical (HPA) axis; they thus provoke the release of glucocorticoids which, in turn, temper the ensuing immune-inflammatory response and thereby complete a homeostatic neuroendocrine-immune regulatory loop. This article reviews the putative mechanisms by which cytokines, released acutely in response to such insults, activate the HPA axis, placing particular emphasis on the actions and interactions of tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and interleukin-6 (IL-6) and on the counter-regulatory mechanisms that are in place.

引用

页码：503 / 521

页数：19

共 97 条

[91] ROLE OF PROSTAGLANDINS E(1), E(2) AND F2-ALPHA IN THE BRAIN IN INTERLEUKIN 1-BETA-INDUCED ADRENOCORTICOTROPIN SECRETION IN THE RAT [J].