Regulators of the cytoplasmic dynein motor

被引：462

作者：

Kardon, Julia R. ^{[3
]}

Vale, Ronald D. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94158 USA

[2] Howard Hughes Med Inst, San Francisco, CA 94158 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ACTIN-RELATED PROTEIN; LISSENCEPHALY GENE LIS1; KINETOCHORE-MICROTUBULE INTERACTIONS; COILED-COIL DOMAIN; BICAUDAL-D; ASPERGILLUS-NIDULANS; DYNACTIN COMPLEX; NUCLEAR MIGRATION; CELL-DIVISION; HEAVY-CHAIN;

D O I：

10.1038/nrm2804

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos. Numerous kinesins and myosins have evolved to cope with the various transport needs that have arisen during eukaryotic evolution. Surprisingly, a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse transport activities as the many different types of kinesin. How is dynein coupled to its wide range of cargos and how is it spatially and temporally regulated? The answer could lie in the several multifunctional adaptors, including dynactin, lissencephaly 1, nuclear distribution protein E (NudE) and NudE-like, Bicaudal d, Rod-ZW10-Zwilch and Spindly, that regulate dynein function and localization.

引用

页码：854 / 865

页数：12

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