15N-15N J-coupling across HgII:: Direct observation of HgII-mediated T-T base pairs in a DNA duplex

被引：486

作者：

Tanaka, Yoshiyuki ^{[1
]}

Oda, Shuji

Yamaguchi, Hiroshi

Kondo, Yoshinori

Kojima, Chojiro

Ono, Akira

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Nara Inst Sci & Technol, Grad Sch Biol Si, Ikoma, Nara 6300101, Japan

[3] Kanagawa Univ, Dept Mat & Life Chem, Fac Engn, Kanazawa Ku, Yokohama, Kanagawa 2218686, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 02期

关键词：

D O I：

10.1021/ja065552h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-N J-coupling across a metal center (2JNN) was clearly detected in a biological macromolecule (DNA duplex) for the first time. By using 2JNN, the base pairing mode of mercury-mediatedT-T pairs (T-HgII-T) was definitely determined. This pairing mode was found to be a novel metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, 2JNN is highly important for the determination of the chemical structures of metal-mediated base pairs. Copyright © 2006 American Chemical Society.

引用

页码：244 / 245

页数：2

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