RNA GG•UU motif binds K+ but not Mg2+

被引：10

作者：

Fan, YP ^{[1
]}

Gaffney, BL ^{[1
]}

Jones, RA ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Biol Chem, Piscataway, NJ 08854 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 50期

关键词：

D O I：

10.1021/ja0555522

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hairpin model of the group I intron P5b loop was synthesized with [8-13C-7-15N]-guanosine in the GG·UU metal binding site, [7-15N]-guanosine at a nonbinding site, and [3-15N]-uridine. 15N NMR showed specific binding for Co(NH3)63+ and K+, but not for Zn2+, Cd2+, or Mg2+. Copyright © 2005 American Chemical Society.

引用

页码：17588 / 17589

页数：2

共 41 条

[1] A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor [J].

Basu, S ;

Rambo, RP ;

Strauss-Soukup, J ;

Cate, JH ;

Ferré-D'Amaré, AR ;

Strobel, SA ;

Doudna, JA .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (11) :986-992

[2] Crystal structure of the ribonucleoprotein core of the signal recognition particle [J].

Batey, RT ;

Rambo, RP ;

Lucast, L ;

Rha, B ;

Doudna, JA .

SCIENCE, 2000, 287 (5456) :1232-+

[3] QUANTITATIVE-EVALUATION OF ELECTROSTATIC AND HYDROGEN-BONDING CONTRIBUTIONS TO METAL COFACTOR BINDING TO NUCLEIC-ACIDS [J].

BLACK, CB ;

COWAN, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (04) :1174-1178

[4] DIAMAGNETIC METAL-ION NUCLEOSIDE INTERACTIONS IN SOLUTION AS STUDIED BY N-15 NUCLEAR MAGNETIC-RESONANCE [J].

BUCHANAN, GW ;

STOTHERS, JB .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1982, 60 (06) :787-791

[5] Metal-binding sites in the major groove of a large ribozyme domain [J].

Cate, JH ;

Doudna, JA .

STRUCTURE, 1996, 4 (10) :1221-1229

[6] A magnesium ion core at the heart of a ribozyme domain [J].

Cate, JH ;

Hanna, RL ;

Doudna, JA .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (07) :553-558

[7]

Chin K, 1999, NAT STRUCT BIOL, V6, P1055

[8] Structure and thermodynamics of metal binding in the P5 helix of a group I intron ribozyme [J].

Colmenarejo, G ;

Tinoco, I .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 290 (01) :119-135

[9] A compact RNA tertiary structure contains a buried Backbone-K+ complex [J].

Conn, GL ;

Gittis, AG ;

Lattman, EE ;

Misra, VK ;

Draper, DE .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 318 (04) :963-973

[10] The two faces of the Escherichia coli 23 S rRNA sarcin/ricin domain:: The structure at 1.11 Å resolution [J].

Correll, CC ;

Wool, IG ;

Munishkin, A .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 292 (02) :275-287

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