NMR screening techniques in drug discovery and drug design

[1] AMEZCUA CA, 2002, KEYST S FRONT STRUCT

[2] Affinity NMR: Decoding DNA binding [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (01): : 69 - 72

[3] NEGATIVE NUCLEAR OVERHAUSER EFFECTS AS PROBES OF MACROMOLECULAR STRUCTURE [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (11) : 4015 - &

[4] CRYSTAL-STRUCTURE OF HUMAN PROTEIN-TYROSINE-PHOSPHATASE 1B [J]. SCIENCE, 1994, 263 (5152) : 1397 - 1404

[5] COMPARISON OF DIFFERENT MODES OF 2-DIMENSIONAL REVERSE-CORRELATION NMR FOR THE STUDY OF PROTEINS [J]. JOURNAL OF MAGNETIC RESONANCE, 1990, 86 (02) : 304 - 318

[6] The properties of known drugs .1. Molecular frameworks [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) : 2887 - 2893

[7] Diffusion edited NMR: Screening compound mixtures by affinity NMR to detect binding ligands to vancomycin [J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (23) : 8486 - 8490

[8] Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (14) : 2664 - 2674

[9] MEASUREMENT OF PROTON RELAXATION RATES IN PROTEINS [J]. JOURNAL OF BIOMOLECULAR NMR, 1993, 3 (03) : 335 - 348

[10] NEW INTRACELLULAR TARGETS FOR THERAPEUTIC DRUG DESIGN [J]. SCIENCE, 1993, 260 (5110) : 918 - 919

[1] AMEZCUA CA, 2002, KEYST S FRONT STRUCT

[2] Affinity NMR: Decoding DNA binding [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (01): : 69 - 72

[3] NEGATIVE NUCLEAR OVERHAUSER EFFECTS AS PROBES OF MACROMOLECULAR STRUCTURE [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (11) : 4015 - &

[4] CRYSTAL-STRUCTURE OF HUMAN PROTEIN-TYROSINE-PHOSPHATASE 1B [J]. SCIENCE, 1994, 263 (5152) : 1397 - 1404

[5] COMPARISON OF DIFFERENT MODES OF 2-DIMENSIONAL REVERSE-CORRELATION NMR FOR THE STUDY OF PROTEINS [J]. JOURNAL OF MAGNETIC RESONANCE, 1990, 86 (02) : 304 - 318

[6] The properties of known drugs .1. Molecular frameworks [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) : 2887 - 2893

[7] Diffusion edited NMR: Screening compound mixtures by affinity NMR to detect binding ligands to vancomycin [J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (23) : 8486 - 8490

[8] Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (14) : 2664 - 2674

[9] MEASUREMENT OF PROTON RELAXATION RATES IN PROTEINS [J]. JOURNAL OF BIOMOLECULAR NMR, 1993, 3 (03) : 335 - 348

[10] NEW INTRACELLULAR TARGETS FOR THERAPEUTIC DRUG DESIGN [J]. SCIENCE, 1993, 260 (5110) : 918 - 919