Neural cams and their role in the development and organization of myelin sheaths

被引:27
作者
Bartsch, U [1 ]
机构
[1] Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2003年 / 8卷
关键词
adhesion molecule; axon; Fyn; dysmyelination; L1; MAG; myelin; NCAM; node of Ranvier; null mutant; oligodendrocyte; paranode; Schwann cell; review;
D O I
10.2741/1028
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Myelination of axons is a prerequisite for the rapid propagation of nerve impulses, and thus for the proper functioning of the nervous system. Phenotypic analysis of genetically engineered mice has provided evidence that cell adhesion molecules are critically involved in the interaction of myelin-forming glial cells with axons, the formation of regularly spaced myelin internodes along axons and the organisation of paranodes and the myelin-free gaps separating the internodes, the nodes of Ranvier. This review will focus on three members of the immunoglobulin-superfamily, the myelin-associated glycoprotein (MAG), the neural cell adhesion molecule (NCAM) and the neural adhesion molecule L1 and will discuss studies on transgenic mice that have analyzed the role of these cell adhesion molecules in the initiation of myelination, formation of structurally intact myelin sheaths and/or maintenance of myelin and axon integrity.
引用
收藏
页码:D477 / D490
页数:14
相关论文
共 157 条
  • [31] Sialic acid specificity of myelin-associated glycoprotein binding
    Collins, BE
    Yang, LJS
    Mukhopadhyay, G
    Filbin, MT
    Kiso, M
    Hasegawa, A
    Schnaar, RL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (02) : 1248 - 1255
  • [32] INACTIVATION OF THE N-CAM GENE IN MICE RESULTS IN SIZE-REDUCTION OF THE OLFACTORY-BULB AND DEFICITS IN SPATIAL-LEARNING
    CREMER, H
    LANGE, R
    CHRISTOPH, A
    PLOMANN, M
    VOPPER, G
    ROES, J
    BROWN, R
    BALDWIN, S
    KRAEMER, P
    SCHEFF, S
    BARTHELS, D
    RAJEWSKY, K
    WILLE, W
    [J]. NATURE, 1994, 367 (6462) : 455 - 459
  • [33] Crocker P R, 1998, Glycobiology, V8, pv
  • [34] Siglecs, sialic acids and innate immunity
    Crocker, PR
    Varki, A
    [J]. TRENDS IN IMMUNOLOGY, 2001, 22 (06) : 337 - 342
  • [35] Disruption of the mouse L1 gene leads to malformations of the nervous system
    Dahme, M
    Bartsch, U
    Martini, R
    Anliker, B
    Schachner, M
    Mantei, N
    [J]. NATURE GENETICS, 1997, 17 (03) : 346 - 349
  • [36] De Bellard M, 1999, J NEUROSCI RES, V56, P213, DOI 10.1002/(SICI)1097-4547(19990415)56:2<213::AID-JNR11>3.0.CO
  • [37] 2-U
  • [38] Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein
    DeBellard, ME
    Tang, S
    Mukhopadhyay, G
    Shen, YJ
    Filbin, MT
    [J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 1996, 7 (02) : 89 - 101
  • [39] Demyanenko GP, 1999, J NEUROSCI, V19, P4907
  • [40] A molecular view on paranodal junctions of myelinated fibers
    Denisenko-Nehrbass, N
    Faivre-Sarrailh, C
    Goutebroze, L
    Girault, JA
    [J]. JOURNAL OF PHYSIOLOGY-PARIS, 2002, 96 (1-2) : 99 - 103