A concise, selective synthesis of the polyketide spacer domain of a potent bryostatin analogue

被引：30

作者：

Wender, PA ^{[1
]}

Mayweg, AVW ^{[1
]}

VanDeusen, CL ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1021/ol0272390

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A concise, asymmetric synthesis of the polyketide spacer domain portion (C1-C13) of a highly potent bryostatin analogue was developed. The route utilizes asymmetric hydrogenation methodology to install the C3, C5, and C11 stereocenters, while a substrate directed syn reduction sets the C9 stereocenter. The spacer domain 1 is obtained in 10 steps with a 25% overall yield and is readily incorporated into the synthesis of 2.

引用

页码：277 / 279

页数：3

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