Attenuated arterial and venous constriction in conscious rats with streptozotocin-induced diabetes

被引:12
作者
Cheng, X [1 ]
Leung, SWS [1 ]
Lim, SL [1 ]
Pang, CCY [1 ]
机构
[1] Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada
关键词
angiotensin; capacitance; diabetes; circulatory filling pressure; mean; noradrenaline; vasoconstriction;
D O I
10.1016/S0014-2999(02)02762-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We examined if arterial or venous constriction is impaired in early diabetes. Dose-pressor and mean circulatory filling pressure (index of venous tone) response curves to noradrenaline and angiotensin II were constructed in four groups of conscious, instrumented, Wistar rats pretreated with streptozotocin (60 mg/kg i.v.) or vehicle at 2 weeks prior to the study. Rats with diabetes, relative to controls, had increased ED50 (reduced potency) for the pressor (2.5-fold of control) and mean circulatory filling pressure (4.3-fold of control) response to noradrenaline, as well as reduced maximum pressor response (efficacy) to noradrenaline (diabetic, 74 +/- 8 mm Hg; control, 96 +/- 5 mm Hg). Diabetic rats also had reduced potency (ED50, 5-fold of control) of the pressor response to angiotensin II; however, maximum pressor response and dose-mean circulatory filling pressure curve to angiotensin II were similar in both groups. Therefore, arterial and venous constrictions are impaired at an early phase of type I diabetes. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:299 / 304
页数:6
相关论文
共 26 条
[1]   RESPONSIVENESS OF SUPERFICIAL HAND VEINS TO ALPHA-ADRENOCEPTOR AGONISTS IN INSULIN-DEPENDENT DIABETIC-PATIENTS [J].
EICHLER, HG ;
BLASCHKE, TF ;
KRAEMER, FB ;
FORD, GA ;
BLOCHLDAUM, B ;
HOFFMAN, BB .
CLINICAL SCIENCE, 1992, 82 (02) :163-168
[2]   EFFECT OF EXPERIMENTAL DIABETES, FOOD-DEPRIVATION AND GENETIC OBESITY ON SENSITIVITY OF PITHED RATS TO AUTONOMIC AGENTS [J].
FOY, JM ;
LUCAS, PD .
BRITISH JOURNAL OF PHARMACOLOGY, 1976, 57 (02) :229-234
[4]  
Guyton A., 1963, Handbook of physiology edited by Hamilton WF circulation, P1099
[5]   MEAN CIRCULATORY FILLING PRESSURE MEASURED IMMEDIATELY AFTER CESSATION OF HEART PUMPING [J].
GUYTON, AC ;
POLIZO, D ;
ARMSTRONG, GG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1954, 179 (02) :261-267
[6]   CHANGES IN BLOOD-PRESSURE, URINARY KALLIKREIN, AND URINARY PROSTAGLANDIN-E2 IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES [J].
HAYASHI, M ;
SENBA, S ;
SAITO, I ;
KITAJIMA, W ;
SARUTA, T .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1983, 322 (04) :290-294
[7]   PRESSOR SENSITIVITIES TO VASOPRESSIN, ANGIOTENSIN-II, OR METHOXAMINE IN DIABETIC RATS [J].
HEBDEN, RA ;
BENNETT, T ;
GARDINER, SM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (05) :R726-R734
[8]   CATECHOLAMINES AND DIABETIC AUTONOMIC NEUROPATHY [J].
HILSTED, J .
DIABETIC MEDICINE, 1995, 12 (04) :296-297
[9]   INFLUENCE OF SHORT-TERM EXPERIMENTAL DIABETES ON BLOOD-PRESSURE AND HEART-RATE IN RESPONSE TO NOREPINEPHRINE AND ANGIOTENSIN-II IN THE CONSCIOUS RAT [J].
JACKSON, CV ;
CARRIER, GO .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1983, 5 (02) :260-265
[10]  
LAURENCE D, 1998, DICT PHARM ALLIED TO