Histocompatible embryonic stem cells by parthenogenesis

被引：154

作者：

Kim, Kitai

Lerou, Paul

Yabuuchi, Akiko

Lengerke, Claudia

Ng, Kitwa

West, Jason

Kirby, Andrew

Daly, Mark J.

Daley, George Q.

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Div Pediat Hematol Oncol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA

[5] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[6] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Newborn Med, Boston, MA 02115 USA

[7] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02115 USA

来源：

SCIENCE | 2007年 / 315卷 / 5811期

关键词：

D O I：

10.1126/science.1133542

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation. After parthenogenetic activation of murine oocytes and interruption of meiosis I or II, we isolated and genotyped pES cells and characterized those that carried the full complement of major histocompatibility complex (MHC) antigens of the oocyte donor. Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients, demonstrating that selected pES cells can serve as a source of histocompatible tissues for transplantation.

引用

页码：482 / 486

页数：5

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