Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs

被引：227

作者：

Lamouille, Samy ^{[1
,2
]}

Subramanyam, Deepa ^{[1
,3
]}

Blelloch, Robert ^{[1
,3
]}

Derynck, Rik ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 02期

关键词：

NEGATIVE FEEDBACK LOOP; TGF-BETA; CELL CHARACTERISTICS; TARGETING ZEB1; CANCER-CELLS; METASTASIS; INVASION; CONTRIBUTES; EXPRESSION; PATHWAY;

D O I：

10.1016/j.ceb.2013.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Epithelial-mesenchymal transition (EMT) and the reverse process, mesenchymal-epithelial transition (MET), are essential during development and in the regulation of stem cell pluripotency, yet these processes are also activated in pathological contexts, such as in fibrosis and cancer progression. In EMT and MET, diverse signaling pathways cooperate in the initiation and progression of the EMT and MET programs, through regulation at transcriptional, post-transcriptional, translational, and post-translational levels. MicroRNAs recently emerged as potent regulators of EMT and MET, with their abilities to target multiple components involved in epithelial integrity or mesenchymal traits. By affecting EMT and MET processes, microRNAs are involved in the regulation of stem cell pluripotency and the control of tumor progression.

引用

收藏

页码：200 / 207

页数：8

相关论文

共 52 条

[1]

MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[2]

Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism [J].

Bhowmick, NA ;

Ghiassi, M ;

Bakin, A ;

Aakre, M ;

Lundquist, CA ;

Engel, ME ;

Arteaga, CL ;

Moses, HL .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (01) :27-36

[3]

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition [J].

Bracken, Cameron P. ;

Gregory, Philip A. ;

Kolesnikoff, Natasha ;

Bert, Andrew G. ;

Wang, Jun ;

Shannon, M. Frances ;

Goodall, Gregory J. .

CANCER RESEARCH, 2008, 68 (19) :7846-7854

[4]

The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 [J].

Gregory, Philip A. ;

Bert, Andrew G. ;

Paterson, Emily L. ;

Barry, Simon C. ;

Tsykin, Anna ;

Farshid, Gelareh ;

Vadas, Mathew A. ;

Khew-Goodall, Yeesim ;

Goodall, Gregory J. .

NATURE CELL BIOLOGY, 2008, 10 (05) :593-601

[5]

Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN [J].

Han, Mingli ;

Liu, Manran ;

Wang, Yimeng ;

Chen, Xin ;

Xu, Jianli ;

Sun, Yan ;

Zhao, Liuyang ;

Qu, Hongbo ;

Fan, Yuanming ;

Wu, Chengyi .

PLOS ONE, 2012, 7 (06)

[6]

Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells [J].

Han, Mingli ;

Liu, Manran ;

Wang, Yimeng ;

Mo, Zhiqiang ;

Bi, Xiaokai ;

Liu, Zhirong ;

Fan, Yuanming ;

Chen, Xin ;

Wu, Chengyi .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2012, 363 (1-2) :427-436

[7]

Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[8]

Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma [J].

Jiang, Lu ;

Liu, Xiqiang ;

Kolokythas, Antonia ;

Yu, Jinsheng ;

Wang, Anxun ;

Heidbreder, Caroline E. ;

Shi, Fei ;

Zhou, Xiaofeng .

INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (03) :505-512

[9]

MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways [J].

Keklikoglou, I. ;

Koerner, C. ;

Schmidt, C. ;

Zhang, J. D. ;

Heckmann, D. ;

Shavinskaya, A. ;

Allgayer, H. ;

Gueckel, B. ;

Fehm, T. ;

Schneeweiss, A. ;

Sahin, Oe ;

Wiemann, S. ;

Tschulena, U. .

ONCOGENE, 2012, 31 (37) :4150-4163

[10]

p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2 [J].

Kim, Taewan ;

Veronese, Angelo ;

Pichiorri, Flavia ;

Lee, Tae Jin ;

Jeon, Young-Jun ;

Volinia, Stefano ;

Pineau, Pascal ;

Marchio, Agnes ;

Palatini, Jeff ;

Suh, Sung-Suk ;

Alder, Hansjuerg ;

Liu, Chang-Gong ;

Dejean, Anne ;

Croce, Carlo M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (05) :875-883

← 1 2 3 4 5 6 →