New roles for integrins in squamous-cell carcinoma

被引：143

作者：

Jones, SM ^{[1
]}

Watt, FM ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, Keratinocyte Lab, London WC2A 3PX, England

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrc1817

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although integrins are known to mediate invasion and metastasis, recent studies reveal new ways in which they contribute to squamous-cell carcinoma. Integrin mutation or upregulation can expand the tumour stem-cell compartment by inhibiting differentiation or apoptosis. Integrins that are expressed by differentiated cells can stimulate or inhibit the proliferation of neighbouring tumour stem cells. These findings provide a mechanistic basis for the well-established links between altered integrin expression and tumour prognosis.

引用

页码：175 / 183

页数：9

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