Association study of the PIN1 gene with Alzheimer's disease

被引：23

作者：

Lambert, JC ^{[1
]}

Bensemain, F ^{[1
]}

Chapuis, J ^{[1
]}

Cottel, D ^{[1
]}

Amouyel, P ^{[1
]}

机构：

[1] Univ Lille 2, Inst Pasteur, INSERM U744, F-59019 Lille, France

来源：

NEUROSCIENCE LETTERS | 2006年 / 402卷 / 03期

关键词：

Alzheimer; PIN1; polymorphism; promoter; association;

D O I：

10.1016/j.neulet.2006.04.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genetic linkage studies indicate evidence for one or more Alzheimer's disease (AD) genes on chromosome 19 independently of the apolipoprotein E gene, a well-characterized AD-risk factor. Recently, the PIN1 gene on chromosome 19p13.2 has been proposed as a candidate gene for AD. Here, we have investigated the potential impact of two promoter polymorphisms (rs2233678 and rs2233679) within this gene on the risk of developing AD. No association of these polymorphisms or haplotypes with the disease was observed in a large French case-control population. Our data suggest that these genetic variants in PIN1 do not make a significant contribution to AD risk. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：259 / 261

页数：3

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