MR imaging of tumor-associated macrophages

被引：29

作者：

Daldrup-Link, Heike ^{[1
]}

Coussens, Lisa M. ^{[2
]}

机构：

[1] Stanford Univ, Mol Imaging Program Stanford, Dept Radiol, Palo Alto, CA 94304 USA

[2] Univ Calif San Francisco, Dept Pathol, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94140 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期

关键词：

magnetic resonance imaging; nanoparticles; contrast agents; tumor associated macrophages; cellular imaging; INFLAMMATION;

D O I：

10.4161/onci.19457

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tumor associated macrophages (TAMs) in breast cancers foster several aspects of tumor progression and metastasis, and represent a biomarker associated with an unfavorable clinical outcome. As new therapeutic agents selectively targeting leukocytes enter the clinic whose mechanism of action involves diminishing macrophage infiltration or presence in tumors, it becomes increasingly important to identify those tumors heavily infiltrated by TAMs, as well as monitoring TAM response to therapy. MR imaging with iron oxide nanoparticles enables noninvasive quantification of TAMs in tumors, and thus, provides an easily accessible ex vivo assessment of TAMs for prognosis and related treatment decisions.

引用

收藏

页数：3

相关论文

共 12 条

[1]

Smoldering and polarized inflammation in the initiation and promotion of malignant disease [J].

Balkwill, F ;

Charles, KA ;

Mantovani, A .

CANCER CELL, 2005, 7 (03) :211-217

[2]

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome [J].

Campbell, Michael J. ;

Tonlaar, Nathan Y. ;

Garwood, Elisabeth R. ;

Huo, Dezheng ;

Moore, Dan H. ;

Khramtsov, Andrey I. ;

Au, Afred ;

Baehner, Frederick ;

Chen, Yinghua ;

Malaka, David O. ;

Lin, Amy ;

Adeyanju, Oyinlolu O. ;

Li, Shihong ;

Gong, Can ;

McGrath, Michael ;

Olopade, Olufunmilayo I. ;

Esserman, Laura J. .

BREAST CANCER RESEARCH AND TREATMENT, 2011, 128 (03) :703-711

[3]

Recent advances in iron oxide nanocrystal technology for medical imaging [J].

Corot, Claire ;

Robert, Philippe ;

Idee, Jean-Marc ;

Port, Marc .

ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1471-1504

[4]

Inflammation and cancer [J].

Coussens, LM ;

Werb, Z .

NATURE, 2002, 420 (6917) :860-867

[5]

Quantification of breast tumor microvascular permeability with feruglose-enhanced MR imaging: Initial phase II multicenter trial [J].

Daldrup-Link, HE ;

Rydland, J ;

Helbich, TH ;

Bjornerud, A ;

Turetschek, K ;

Kvistad, KA ;

Kaindl, E ;

Link, TM ;

Staudacher, K ;

Shames, D ;

Brasch, RC ;

Haraldseth, O ;

Rummeny, EJ .

RADIOLOGY, 2003, 229 (03) :885-892

[6]

Imaging of tumor angiogenesis: Current approaches and future prospects [J].

Daldrup-Link, Heike E. ;

Simon, Gerhard H. ;

Brasch, Robert C. .

CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (21) :2661-2672

[7]

MRI of Tumor-Associated Macrophages with Clinically Applicable Iron Oxide Nanoparticles [J].

Daldrup-Link, Heike E. ;

Golovko, Daniel ;

Ruffell, Brian ;

DeNardo, David G. ;

Castaneda, Rosalinda ;

Ansari, Celina ;

Rao, Jianghong ;

Tikhomirov, Grigory A. ;

Wendland, Michael F. ;

Corot, Claire ;

Coussens, Lisa M. .

CLINICAL CANCER RESEARCH, 2011, 17 (17) :5695-5704

[8]

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy [J].

DeNardo, David G. ;

Brennan, Donal J. ;

Rexhepaj, Elton ;

Ruffell, Brian ;

Shiao, Stephen L. ;

Madden, Stephen F. ;

Gallagher, William M. ;

Wadhwani, Nikhil ;

Keil, Scott D. ;

Junaid, Sharfaa A. ;

Rugo, Hope S. ;

Hwang, E. Shelley ;

Jirstroem, Karin ;

West, Brian L. ;

Coussens, Lisa M. .

CANCER DISCOVERY, 2011, 1 (01) :54-67

[9]

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages [J].

DeNardo, David G. ;

Barreto, Jairo B. ;

Andreu, Pauline ;

Vasquez, Lesley ;

Tawfik, David ;

Kolhatkar, Nikita ;

Coussens, Lisa M. .

CANCER CELL, 2009, 16 (02) :91-102

[10]

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression [J].

Doedens, Andrew L. ;

Stockmann, Christian ;

Rubinstein, Mark P. ;

Liao, Debbie ;

Zhang, Na ;

DeNardo, David G. ;

Coussens, Lisa M. ;

Karin, Michael ;

Goldrath, Ananda W. ;

Johnson, Randall S. .

CANCER RESEARCH, 2010, 70 (19) :7465-7475