Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

被引：571

作者：

Taylor, DR

Shi, ST

Romano, PR

Barber, GN

Lai, MMC ^{[1
]}

机构：

[1] Univ So Calif, Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90089 USA

[2] Univ So Calif, Sch Med, Howard Hughes Med Inst, Los Angeles, CA 90089 USA

[3] Small Mol Therapeut, Monmouth Junction, NJ 08852 USA

[4] Univ Miami, Sch Med, Miami, FL 33136 USA

来源：

SCIENCE | 1999年 / 285卷 / 5424期

关键词：

D O I：

10.1126/science.285.5424.107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2 alpha, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.

引用

页码：107 / 110

页数：4