Determinants of histone H1 mobility and chromatin binding in living cells

被引：132

作者：

Catez, F ^{[1
]}

Ueda, T ^{[1
]}

Bustin, M ^{[1
]}

机构：

[1] NCI, Lab Metab, US Natl Inst Hlth, Bethesda, MD 20892 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 04期

关键词：

D O I：

10.1038/nsmb1077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dynamic interaction of chromatin-binding proteins with their nucleosome binding sites is an important element in regulating the structure and function of chromatin in living cells. Here we review the major factors regulating the intranuclear mobility and chromatin binding of the linker histone H1, the most abundant family of nucleosome-binding proteins. The information available reveals that multiple and diverse factors modulate the interaction of H1 with chromatin at both a local and global level. This multifaceted mode of modulating the interaction of H1 with nucleosomes is part of the mechanism that regulates the dynamics of the chromatin fiber in living cells.

引用

页码：305 / 310

页数：6

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