Prion protein interconversions and the transmissible spongiform encephalopathies

被引：82

作者：

Horiuchi, M ^{[1
]}

Caughey, B ^{[1
]}

机构：

[1] NIAID, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA

来源：

STRUCTURE | 1999年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0969-2126(00)80049-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autocatalytic changes in the conformation and aggregation state of prion protein appear to be fundamental to transmissible spongiform encephalopathies or prion diseases. Here we review the considerable progress that has been made in describing the normal properties of prion protein and the changes that occur during these devastating neurodegenerative diseases.

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页码：R231 / R240

页数：10

相关论文

共 95 条

[1] DISTINCT PRP PROPERTIES SUGGEST THE MOLECULAR-BASIS OF STRAIN VARIATION IN TRANSMISSIBLE MINK ENCEPHALOPATHY [J].

BESSEN, RA ;

MARSH, RF .

JOURNAL OF VIROLOGY, 1994, 68 (12) :7859-7868

[2] In situ formation of protease-resistant prion protein in transmissible spongiform encephalopathy-infected brain slices [J].

Bessen, RA ;

Raymond, GJ ;

Caughey, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) :15227-15231

[3] NONGENETIC PROPAGATION OF STRAIN-SPECIFIC PROPERTIES OF SCRAPIE PRION PROTEIN [J].

BESSEN, RA ;

KOCISKO, DA ;

RAYMOND, GJ ;

NANDAN, S ;

LANSBURY, PT ;

CAUGHEY, B .

NATURE, 1995, 375 (6533) :698-700

[4]

BOLTON DC, 1988, NOVEL INFECTIOUS AGE, P164

[5]

BORCHELT DR, 1992, J BIOL CHEM, V267, P16188

[6] Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms [J].

Bossers, A ;

Belt, PBGM ;

Raymond, GJ ;

Caughey, B ;

deVries, R ;

Smits, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :4931-4936

[7] Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: Implications for the mechanism of prion formation [J].

Cappai, R ;

Stewart, L ;

Jobling, MF ;

Thyer, JM ;

White, AR ;

Beyreuther, K ;

Collins, SJ ;

Masters, CL ;

Barrow, CJ .

BIOCHEMISTRY, 1999, 38 (11) :3280-3284

[8]

CAUGHEY B, 1991, J BIOL CHEM, V266, P18217

[9] N-TERMINAL TRUNCATION OF THE SCRAPIE-ASSOCIATED FORM OF PRP BY LYSOSOMAL PROTEASE(S) - IMPLICATIONS REGARDING THE SITE OF CONVERSION OF PRP TO THE PROTEASE-RESISTANT STATE [J].

CAUGHEY, B ;

RAYMOND, GJ ;

ERNST, D ;

RACE, RE .

JOURNAL OF VIROLOGY, 1991, 65 (12) :6597-6603

[10] Strain-dependent differences in β-sheet conformations of abnormal prion protein [J].

Caughey, B ;

Raymond, GJ ;

Bessen, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (48) :32230-32235

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